Justifications for secession:

• United States President James Buchanan, Fourth Annual Message to Congress on the State of the Union December 3, 1860: "The fact is that our Union rests upon public opinion, and can never be cemented by the blood of its citizens shed in civil war. If it can not live in the affections of the people, it must one day perish. Congress possesses many means of preserving it by conciliation, but the sword was not placed in their hand to preserve it by force."
• Former President Thomas Jefferson, in a letter to William H. Crawford, Secretary of War under President James Madison, on June 20, 1816: "In your letter to Fisk, you have fairly stated the alternatives between which we are to choose: 1, licentious commerce and gambling speculations for a few, with eternal war for the many; or, 2, restricted commerce, peace, and steady occupations for all. If any State in the Union will declare that it prefers separation with the first alternative, to a continuance in union without it, I have no hesitation in saying, 'let us separate.' I would rather the States should withdraw, which are for unlimited commerce and war, and confederate with those alone which are for peace and agriculture."^[26]
• Economic enfranchisement of an economically oppressed class that is regionally concentrated within the scope of a larger national territory.
• The right to liberty, freedom of association and private property
• Consent as important democratic principle; will of majority to secede should be recognized
• Making it easier for states to join with others in an experimental union
• Dissolving such union when goals for which it was constituted are not achieved
• Self-defense when larger group presents lethal threat to minority or the government cannot adequately defend an area
• Self-determination of peoples
• Preserving culture, language, etc. from assimilation or destruction by a larger or more powerful group
• Furthering diversity by allowing diverse cultures to keep their identity
• Rectifying past injustices, especially past conquest by a larger power
• Escaping "discriminatory redistribution", i.e., tax schemes, regulatory policies, economic programs, etc. that distribute resources away to another area, especially in an undemocratic fashion
• Enhanced efficiency when the state or empire becomes too large to administer efficiently
• Preserving "liberal purity" (or "conservative purity") by allowing less (or more) liberal regions to secede
• Providing superior constitutional systems which allow flexibility of secession
• Keeping political entities small and human scale through right to secession

Political scientist Aleksander Pavkovic describes five justifications for a general right of secession within liberal political theory:^[27]

• Anarcho-Capitalism: individual liberty to form political associations and private property rights together justify right to secede and to create a "viable political order" with like-minded individuals.
• Democratic Secessionism: the right of secession, as a variant of the right of self-determination, is vested in a "territorial community" which wishes to secede from "their existing political community"; the group wishing to secede then proceeds to delimit "its" territory by the majority.
• Communitarian Secessionism: any group with a particular "participation-enhancing" identity, concentrated in a particular territory, which desires to improve its members' political participation has a prima facie right to secede.
• Cultural Secessionism: any group which was previously in a minority has a right to protect and develop its own culture and distinct national identity through seceding into an independent state.
• The Secessionism of Threatened Cultures: if a minority culture is threatened within a state that has a majority culture, the minority needs a right to form a state of its own which would protect its culture.